The IARC classification scheme
IARC have a five-point scale for classifying agents in their
monographs:
| Group 1 |
The agent is carcinogenic to humans |
| Group 2A |
The agent is probably carcinogenic to humans |
| Group 2B |
The agent is possibly carcinogenic to humans |
| Group 3 |
The agent is possibly carcinogenic to humans |
| Group 4 |
The agent is possibly carcinogenic to humans |
Note that IARC say: "The terms probably carcinogenic and possibly carcinogenic have no quantitative significance and are used simply as descriptors of different levels of evidence of human carcinogenicity, with probably carcinogenic signifying a higher level of evidence than possibly carcinogenic."
IARC have quite complicated but precise rules for deriving the overall classification from the separate classifications of the animal and human evidence. We summarise them here. We colour each box according to the normal classification it produces. Where there are alternative classifications, we list these in brackets - these often have to do with mechanistic evidence which is not captured in either the human or animal evidence, and there are one or two further exceptions as well which don't fit neatly in this presentation.
|
Animals |
| Sufficient |
Limited |
Inadequate |
Suggesting Lack |
| humans |
Sufficient |
1 |
1 |
1 |
1 |
| Limited |
2A (1) |
2B (2A) |
2B (2A) |
2B (2A) |
| Inadequate |
2B (1, 2A, 3) |
3 (2B) |
3 |
3 (4) |
| Suggesting Lack |
3 (1) |
3 |
3 |
4 |
On this same grid, the following version shows where EMFs are classified (more):
|
Animals |
| Sufficient |
Limited |
Inadequate |
Suggesting Lack |
| humans |
Sufficient |
1 |
1 |
1 |
1 |
| Limited |
2A (1) |
2B (2A) |
ELF magnetic fields |
2B (2A) |
| Inadequate |
2B (1, 2A, 3) |
3 (2B) |
ELF electric fields |
3 (4) |
| Suggesting Lack |
3 (1) |
3 |
3 |
4 |
|